At Manhattan Pain Medicine, we help patients with complex, persistent, or unexplained pain move beyond trial-and-error care. Our diagnosis-first approach looks deeper to understand what is generating the pain, how it developed, and what path forward makes sense.
There is rarely one simple explanation for complex pain. Symptoms may involve joints, nerves, muscles, inflammation, connective tissue, the autonomic nervous system, prior injury, medical trauma, or the way the body has learned to protect itself over time.
At Manhattan Pain Medicine, we do not begin with a one-size-fits-all treatment plan. We begin with Discovery. Our team listens carefully, reviews the full history, examines how the body moves and responds, and builds a clinical hypothesis before recommending the next step.
But precision does not mean losing sight of the person. We treat the patient behind the pain: their story, their function, their fears, their goals, and the life they are trying to return to.
The goal is not only to reduce pain, but to understand it, and to help each patient move forward with greater clarity, confidence, and support.
Explore the Zones of Expertise by clicking or tapping on a circle.
Founder and Medical Director of Manhattan Pain Medicine, triple board-certified in Physical Medicine and Rehabilitation, Pain Medicine, and Headache Medicine.
Board-certified rheumatologist and internal medicine physician specializing in autoimmune, inflammatory, dysautonomia-related, and complex pain conditions.
Fellowship-trained Interventional Pain Management specialist focused on complex chronic pain, autoimmune-related pain, hypermobility, spine pain, nerve pain, and joint pain.
Board-certified Physical Medicine and Rehabilitation specialist focused on pelvic pain, pelvic floor dysfunction, chronic pain, and sexual wellness.
Health and Pain Psychologist integrating psychology, mind-body care, acupuncture, and nervous system regulation for complex chronic pain.
Board-certified Physician Assistant specializing in orthopedic and spine care, clinical intake, and diagnosis-first pain evaluation.
Board-certified Physician Assistant specializing in rheumatology, neurology, headache, autoimmune, and complex pain care.
These guys are the best. I've been going here for over 6 years and their familiarity with my Schwannomatosis (most ppl have never even heard of it - its rather rare) and their ability to diagnose my CRPS quickly and accurately and then treat it like I was merely getting a flu shot is just incredible...
Highly recommended for those who need Pain Management. Everyone at Manhattan Pain Medicine is extremely nice and helpful. I have had very good interactions with both Dr. Siefferman and Dr. Louis. All of the staff is very responsive. 5 stars.
The providers at Manhattan Pain Medicine are exceptional. I wish I had found them 30 years ago!
I genuinely can’t say enough good things about the team at Manhattan Pain Medicine. I have MCAS, EDS, and an inflammatory autoimmune disease, and I’ve basically been searching for answers since I was a kid. I had years of unexplained inflammation markers, chronic pain, and allergic reactions despite...
I have a complex medical history and have seen a lot of doctors over the years. Dr. Mikaberidze and Dr. Siefferman each took the time to really listen and understand everything I had been dealing with. I also appreciated how they work together and communicated about my care. I left with a plan that...
Sharing my gratitude for the pleasant experience last week during my visit, the medical team provided great care and also treated my session as a learning experience, I left my session with a wealth of knowledge. A big thank you to the kind, and professional staff who welcomed me to the office as a...
I cannot say enough good things about Manhattan Pain Medicine. From the moment I walked in, I felt truly cared for and taken seriously. Dr. Nino Mikaberidze, Director of Rheumatology, is exceptional — knowledgeable, compassionate, and incredibly thorough. She takes the time to listen, explains every...
Dr Siefferman is the most thorough, patient doctor I have even been to. Currently I travel from miami to nyc to see him because his bed side manner and desire to help is incomparable.
ZocDoc
This practice is wonderful. I have been a patient of Dr. Siefferman’s since 2019 and he’s extremely helpful and kind. He has brought in a Rheumatologist who is also great. They handle very complex pain issues and always try to find new ways to help me.
Dr. Siefferman is an incredible doctor! He is extremely diligent and knowledgeable. It feels like you are his only patient. He invests a lot of time and effort into your injuries and concerns. I did not find these wonderful qualities with other pain specialists before, who were always rushed and som...
ZocDoc
Dr. Siefferman is a doctor who combines the old world bedside manner of doctors from my childhood (60 years ago) with a sta te of the art embrace of modern technology. It is always a pleasure to have an appointment with him...always has options and solutions to my medical issues. He is truly the doc...
ZocDoc
Dr. Siefferman is a genius. He is very informed and listens attentively.
ZocDoc
Dr. Siefferman and his entire team continue to be efficient, dedicated, and driven by precision and a genuine desire to give fantastic care. Will always recommend.
ZocDoc
Doctor Siefferman is fantastic. Have been seeing him for 5 years. Couldn’t recommend more.
ZocDoc
Dr. Siefferman is the ONLY doctor who has ever been able to diagnose my pain and treat it. He is hands down the best
ZocDoc
Before care begins, our team helps patients understand the practical side of treatment, including insurance verification, out-of-network benefits, cost-share estimates, self-pay options, and billing questions. We believe patients should have as much clarity as possible before moving forward.
