Luis Aranguren, MD

Interventional Pain Management

Dr. Aranguren is a fellowship-trained Interventional Pain Management specialist at Manhattan Pain Medicine. He focuses on complex chronic pain, autoimmune-related pain, hypermobility, Ehlers-Danlos syndrome, spine-related pain, neuropathic pain, joint pain, and post-surgical pain.

Credentials and Organizations

Memberships

  • American Medical Association (AMA)
  • Future Health Professionals Association (FPS)

Departments

  • Interventional Pain Management

About Dr. Luis Aranguren

Clinical Background

Dr. Aranguren is a fellowship-trained Interventional Pain Management physician with advanced training in anesthesiology and pain medicine. He earned his medical degree from the University of Puerto Rico School of Medicine, completed anesthesiology residency training at HCA/USF near Tampa, Florida, and completed an Interventional Pain Management fellowship at John H. Stroger, Jr. Hospital of Cook County in Chicago.

Clinical Focus

Dr. Aranguren is drawn to complex, multisystem pain presentations. His clinical focus includes autoimmune-related pain, hypermobility, Ehlers-Danlos syndrome, complex chronic pain, lumbar and cervical radiculopathy, facet-mediated back and neck pain, sacroiliac joint dysfunction, peripheral nerve pain, myofascial pain, osteoarthritis, tendinopathies, and post-surgical pain.

Treatment Approach

Dr. Aranguren builds treatment plans that may include image-guided injections, radiofrequency ablation, targeted medication management, and movement-based rehabilitation, along with practical lifestyle and nutrition guidance. His approach emphasizes clear plans, measurable relief, restored function, and long-term self-management.

Role at MPM

At Manhattan Pain Medicine, Dr. Aranguren leads care for many patients with complex chronic pain presentations. He provides comprehensive physician consultations, coordinates closely with physical therapists and referring clinicians, and supports continuity of care through follow-up visits and telemedicine when clinically appropriate.

Background

Dr. Aranguren was born and raised in San Juan, Puerto Rico and is bilingual in English and Spanish.

Comprehensive Care for Complex Pain

Dr. Aranguren helps patients with overlapping pain conditions move through a clear, coordinated treatment plan focused on diagnosis, function, and measurable progress.

Clinical Role at Manhattan Pain Medicine

Dr. Aranguren’s role is especially important for patients whose symptoms involve multiple systems or overlapping pain generators. His work combines careful clinical evaluation, interventional pain procedures, medication management, rehabilitation coordination, and ongoing treatment planning.

“I’m here to listen, understand what you’re going through, and help guide you toward meaningful pain relief so you can get back to living your life.”

 

Dr. Aranguren supports MPM’s diagnosis-first approach to complex chronic pain care.

Conditions Dr. Aranguren Treats

A Clearer Plan for Overlapping Pain

Many patients with chronic pain have more than one active pain generator. Dr. Aranguren works to identify the systems involved, select treatments in the right order, and coordinate care around comfort, function, and long-term management.

PATIENT STORIES

Real Patients. Real Progress.

Hear from patients who came to Manhattan Pain Medicine looking for answers, clarity, and a more thoughtful path forward.
  • Michael O.

    5 star review

    These guys are the best. I've been going here for over 6 years and their familiarity with my Schwannomatosis (most ppl have never even heard of it - its rather rare) and their ability to diagnose my CRPS quickly and accurately and then treat it like I was merely getting a flu shot is just incredible...

    Google

  • John A.

    5 star review

    Highly recommended for those who need Pain Management. Everyone at Manhattan Pain Medicine is extremely nice and helpful. I have had very good interactions with both Dr. Siefferman and Dr. Louis. All of the staff is very responsive. 5 stars.

    Google

  • Rakhee K.

    5 star review

    The providers at Manhattan Pain Medicine are exceptional. I wish I had found them 30 years ago!

    Google

  • Annie R.

    5 star review

    I genuinely can’t say enough good things about the team at Manhattan Pain Medicine. I have MCAS, EDS, and an inflammatory autoimmune disease, and I’ve basically been searching for answers since I was a kid. I had years of unexplained inflammation markers, chronic pain, and allergic reactions despite...

    Google

  • Karine S.

    5 star review

    I have a complex medical history and have seen a lot of doctors over the years. Dr. Mikaberidze and Dr. Siefferman each took the time to really listen and understand everything I had been dealing with. I also appreciated how they work together and communicated about my care. I left with a plan that...

    Google

  • Edwin F-S.

    5 star review

    Sharing my gratitude for the pleasant experience last week during my visit, the medical team provided great care and also treated my session as a learning experience, I left my session with a wealth of knowledge. A big thank you to the kind, and professional staff who welcomed me to the office as a...

    Google

  • Madaline. M

    5 star review

    I cannot say enough good things about Manhattan Pain Medicine. From the moment I walked in, I felt truly cared for and taken seriously. Dr. Nino Mikaberidze, Director of Rheumatology, is exceptional — knowledgeable, compassionate, and incredibly thorough. She takes the time to listen, explains every...

    Google

  • Lauren W.

    5 star review

    Dr Siefferman is the most thorough, patient doctor I have even been to. Currently I travel from miami to nyc to see him because his bed side manner and desire to help is incomparable.

    ZocDoc

  • Dana S.

    5 star review

    This practice is wonderful. I have been a patient of Dr. Siefferman’s since 2019 and he’s extremely helpful and kind. He has brought in a Rheumatologist who is also great. They handle very complex pain issues and always try to find new ways to help me.

    Google

  • Frans M.

    5 star review

    Dr. Siefferman is an incredible doctor! He is extremely diligent and knowledgeable. It feels like you are his only patient. He invests a lot of time and effort into your injuries and concerns. I did not find these wonderful qualities with other pain specialists before, who were always rushed and som...

    ZocDoc

  • Gregory S.

    5 star review

    Dr. Siefferman is a doctor who combines the old world bedside manner of doctors from my childhood (60 years ago) with a sta te of the art embrace of modern technology. It is always a pleasure to have an appointment with him...always has options and solutions to my medical issues. He is truly the doc...

    ZocDoc

  • Judith R.

    5 star review

    Dr. Siefferman is a genius. He is very informed and listens attentively.

    ZocDoc

  • Joshua M.

    5 star review

    Dr. Siefferman and his entire team continue to be efficient, dedicated, and driven by precision and a genuine desire to give fantastic care. Will always recommend.

    ZocDoc

  • Michael W. S

    5 star review

    Doctor Siefferman is fantastic. Have been seeing him for 5 years. Couldn’t recommend more.

    ZocDoc

  • Stephanie G.

    5 star review

    Dr. Siefferman is the ONLY doctor who has ever been able to diagnose my pain and treat it. He is hands down the best

    ZocDoc

Understanding Insurance Before You Begin

Before care begins, our team helps patients understand the practical side of treatment, including insurance verification, out-of-network benefits, cost-share estimates, self-pay options, and billing questions. We believe patients should have as much clarity as possible before moving forward.

Insurance & Billing

Pain Care That Starts With Understanding

When pain is complex, the first step should not be another generic treatment. Manhattan Pain Medicine looks deeper to understand what is driving the pain, why it has persisted, and what path forward makes sense for you.

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CREDENTIALS

Education, Credentials & Research

Dr. Aranguren’s credentials include medical training, anesthesiology residency, fellowship training in Interventional Pain Management, professional memberships, and research and publication experience.