Infusion Therapy in Manhattan and NYC

Infusion therapy may be considered for selected chronic pain, neuropathic pain, CRPS, autoimmune-related pain, inflammatory arthritis, and complex pain conditions.

Learn how Dr. Aranguren uses infusion therapy as part of a personalized pain management plan to help reduce symptoms, improve function, and support long-term relief.

What Is Infusion Therapy?

Infusion therapy is a medically supervised treatment category that delivers medication through an IV or infusion-based approach. In pain and inflammatory care, different infusions may serve different purposes. Some may be considered for selected chronic pain, neuropathic pain, CRPS, or treatment-resistant pain patterns. Others, such as biologic infusions, may be used for certain autoimmune or inflammatory conditions.

At Manhattan Pain Medicine, infusion therapy is not approached as a wellness IV service or a one-size-fits-all treatment. It begins with a diagnosis-first evaluation to determine whether an infusion is appropriate, which type may fit the condition, and what monitoring or specialist coordination may be needed.

Specialist-Guided Infusion Planning

MPM specialists evaluate infusion therapy by first clarifying the patient’s diagnosis, treatment history, medical risks, current medications, symptoms, and care goals. A patient with autoimmune-related pain may need a very different infusion plan than a patient with neuropathic pain, CRPS, chronic migraine, spine-related pain, or complex chronic pain.

Some patients may require lab review, infection screening, medication clearance, vital sign monitoring, or coordination with rheumatology, neurology, oncology, primary care, or another treating clinician. The goal is to match the infusion type to the diagnosis and safety profile rather than treating infusions as interchangeable.

Different Infusions Serve Different Goals

Infusion therapy is not one treatment. It is a category that may include different medications, protocols, monitoring requirements, risks, and clinical goals. Ketamine therapy may be considered for selected complex pain or treatment-resistant pain patterns. Lidocaine-based infusions may be considered in certain neuropathic pain contexts. Biologic infusions may be used for inflammatory or autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, psoriasis-related disease, or other immune-mediated conditions when clinically appropriate.

This distinction matters because the benefits and risks are not the same across infusion types. Ketamine can involve sedation, dissociation, mood effects, and blood pressure or heart rate changes. Lidocaine requires cardiac and neurologic safety consideration. Biologics may involve immune suppression, infection risk, infusion reactions, and lab monitoring. At MPM, infusion therapy is integrated into coordinated care, not used as a generic solution for chronic pain or inflammation.

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Treatment Process

How MPM Approaches Infusion Therapy

MPM uses a diagnosis-first process to determine whether infusion therapy is appropriate, which type may fit, and how it should be monitored.
  • 1

    Clarify the Diagnosis

    The process begins with a review of symptoms, diagnosis, prior treatments, medication history, exam findings, imaging, labs when relevant, and functional impact. MPM considers whether the condition involves neuropathic pain, CRPS, autoimmune-related pain, inflammatory arthritis, headache, spine-related pain, or another complex pain pattern.
  • 2

    Match the Infusion Type

    Different infusions have different purposes. MPM considers whether the patient’s condition may align with ketamine therapy, lidocaine and ketamine infusions, biologic infusions, or another medically supervised infusion approach. The treatment goal may involve pain modulation, neuropathic pain support, inflammatory disease treatment, or immune-directed care.
  • 3

    Review Safety and Monitoring

    Infusion therapy may require medication review, lab monitoring, infection screening, medical clearance, vital sign monitoring, and post-infusion observation. MPM reviews medical history, current medications, cardiovascular risk, neurologic risk, infection risk, mental health history, immune status, and condition-specific safety considerations before treatment.
  • 4

    Coordinate Ongoing Care

    After an infusion, MPM tracks response, side effects, function, pain burden, and next steps. If treatment helps, repeat infusions may be considered only when appropriate. If response is limited or safety concerns arise, the plan may shift toward another treatment, further evaluation, or specialist coordination.

Infusions Across MPM’s Pain Expertise

Infusion therapy may intersect with several MPM Zones of Expertise, including Complex Chronic Pain, Autoimmune and Inflammatory pain, Psychology of Pain, Headache, Musculoskeletal issues, and neuropathic pain patterns. In complex chronic pain, certain infusions may be considered when symptoms remain severe despite standard treatments. In autoimmune or inflammatory pain, biologic infusions may be part of immune-directed care when clinically appropriate. In neuropathic pain or CRPS, infusion-based strategies may be considered selectively after careful evaluation.

MPM does not treat all infusions as the same. The team considers diagnosis, prior treatment response, medical risks, specialist involvement, monitoring needs, and whether infusion therapy should be combined with other care, such as medication management, pain psychology, physical rehabilitation, procedures, biologics, or specialist coordination.

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What to Expect During an Infusion Visit

Before an infusion, MPM reviews the treatment type, diagnosis, goals, risks, medications, monitoring plan, and any preparation requirements. Depending on the infusion, patients may need lab work, infection screening, medical clearance, medication adjustments, transportation planning, or coordination with another treating clinician. During the visit, medication is delivered through an IV or infusion system while the care team monitors for safety and response.

The experience varies by infusion type. Some patients may require vital sign monitoring, observation after treatment, or specific post-infusion instructions. Potential side effects may include infusion reactions, nausea, dizziness, sedation, mood effects, blood pressure or heart rate changes, allergic reaction, infection risk, or condition-specific adverse effects. Patients should report unusual symptoms promptly. Follow-up helps determine whether the infusion supported the treatment goal or whether the care plan should be adjusted.

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PATIENT STORIES

Real Patients. Real Progress.

Hear from patients who came to Manhattan Pain Medicine looking for answers, clarity, and a more thoughtful path forward.
  • Michael O.

    5 star review

    These guys are the best. I've been going here for over 6 years and their familiarity with my Schwannomatosis (most ppl have never even heard of it - its rather rare) and their ability to diagnose my CRPS quickly and accurately and then treat it like I was merely getting a flu shot is just incredible...

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  • John A.

    5 star review

    Highly recommended for those who need Pain Management. Everyone at Manhattan Pain Medicine is extremely nice and helpful. I have had very good interactions with both Dr. Siefferman and Dr. Louis. All of the staff is very responsive. 5 stars.

    Google

  • Rakhee K.

    5 star review

    The providers at Manhattan Pain Medicine are exceptional. I wish I had found them 30 years ago!

    Google

  • Annie R.

    5 star review

    I genuinely can’t say enough good things about the team at Manhattan Pain Medicine. I have MCAS, EDS, and an inflammatory autoimmune disease, and I’ve basically been searching for answers since I was a kid. I had years of unexplained inflammation markers, chronic pain, and allergic reactions despite...

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  • Karine S.

    5 star review

    I have a complex medical history and have seen a lot of doctors over the years. Dr. Mikaberidze and Dr. Siefferman each took the time to really listen and understand everything I had been dealing with. I also appreciated how they work together and communicated about my care. I left with a plan that...

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  • Edwin F-S.

    5 star review

    Sharing my gratitude for the pleasant experience last week during my visit, the medical team provided great care and also treated my session as a learning experience, I left my session with a wealth of knowledge. A big thank you to the kind, and professional staff who welcomed me to the office as a...

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  • Madaline. M

    5 star review

    I cannot say enough good things about Manhattan Pain Medicine. From the moment I walked in, I felt truly cared for and taken seriously. Dr. Nino Mikaberidze, Director of Rheumatology, is exceptional — knowledgeable, compassionate, and incredibly thorough. She takes the time to listen, explains every...

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  • Lauren W.

    5 star review

    Dr Siefferman is the most thorough, patient doctor I have even been to. Currently I travel from miami to nyc to see him because his bed side manner and desire to help is incomparable.

    ZocDoc

  • Dana S.

    5 star review

    This practice is wonderful. I have been a patient of Dr. Siefferman’s since 2019 and he’s extremely helpful and kind. He has brought in a Rheumatologist who is also great. They handle very complex pain issues and always try to find new ways to help me.

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  • Frans M.

    5 star review

    Dr. Siefferman is an incredible doctor! He is extremely diligent and knowledgeable. It feels like you are his only patient. He invests a lot of time and effort into your injuries and concerns. I did not find these wonderful qualities with other pain specialists before, who were always rushed and som...

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  • Gregory S.

    5 star review

    Dr. Siefferman is a doctor who combines the old world bedside manner of doctors from my childhood (60 years ago) with a sta te of the art embrace of modern technology. It is always a pleasure to have an appointment with him...always has options and solutions to my medical issues. He is truly the doc...

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  • Judith R.

    5 star review

    Dr. Siefferman is a genius. He is very informed and listens attentively.

    ZocDoc

  • Joshua M.

    5 star review

    Dr. Siefferman and his entire team continue to be efficient, dedicated, and driven by precision and a genuine desire to give fantastic care. Will always recommend.

    ZocDoc

  • Michael W. S

    5 star review

    Doctor Siefferman is fantastic. Have been seeing him for 5 years. Couldn’t recommend more.

    ZocDoc

  • Stephanie G.

    5 star review

    Dr. Siefferman is the ONLY doctor who has ever been able to diagnose my pain and treat it. He is hands down the best

    ZocDoc

FAQs About Infusion Therapy

Related Infusion-Based Treatments

Related treatments may be considered depending on the patient’s diagnosis, infusion type, treatment goals, monitoring needs, and response.

Understanding Insurance Before You Begin

Before care begins, our team helps patients understand the practical side of treatment, including insurance verification, out-of-network benefits, cost-share estimates, self-pay options, and billing questions. We believe patients should have as much clarity as possible before moving forward.

Insurance & Billing

Pain Care That Starts With Understanding

When pain is complex, the first step should not be another generic treatment. Manhattan Pain Medicine looks deeper to understand what is driving the pain, why it has persisted, and what path forward makes sense for you.

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Insights & Research

Explore MPM Insights and Research, including patient-friendly articles, clinical perspectives, and research from our team to help explain how we understand complex pain, evaluate care options, and guide the path to treatment
In Depth

Infusion Therapy for Pain and Inflammatory Care

Infusion therapy may support selected patients when the infusion type, diagnosis, safety profile, and treatment goal are carefully matched.

Infusion Therapy

Infusion therapy is a medically supervised treatment category, not a single treatment. In pain and inflammatory care, infusions may include different medications with different goals, risks, monitoring requirements, and expected outcomes. Some infusions are used to support selected chronic pain or neuropathic pain patterns. Others are used to treat autoimmune or inflammatory disease activity. Some patients search for infusion therapy NYC care after standard treatments have not provided enough relief, while others are referred for a specific infusion type such as ketamine therapy, lidocaine-based infusions, or biologics.

At Manhattan Pain Medicine (MPM), infusions are approached through a diagnosis-first model. The goal is to determine whether an infusion is clinically appropriate, which type may fit the diagnosis, and how it should be coordinated with the rest of the care plan.

Infusions for Chronic and Neuropathic Pain

Chronic pain can involve many different mechanisms, including nerve irritation, central sensitization, inflammation, spine-related pain, CRPS, small fiber neuropathy, autoimmune disease, headache disorders, and complex overlapping pain patterns. Infusion therapy for chronic pain in Manhattan may be considered when symptoms are persistent, disabling, and not adequately controlled with standard care.

Ketamine and lidocaine infusions for chronic pain may be considered for selected patients, but they are not universal treatments. Ketamine has been studied for certain treatment-resistant and neuropathic pain conditions, including CRPS, but evidence and durability vary. Lidocaine-based infusions have been studied for neuropathic pain and require careful cardiac and neurologic safety assessment. MPM evaluates whether these options fit the patient’s diagnosis, medical risks, and care goals before proceeding.

Infusions for Autoimmune and Inflammatory Pain

Autoimmune infusion therapy NYC care is different from pain-modulating infusion therapy. Biologic infusions are immune-directed treatments used for selected inflammatory conditions, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, psoriasis-related disease, or other autoimmune conditions when clinically appropriate. These medications are designed to reduce inflammatory activity by targeting specific immune pathways.

Biologic infusions are not general pain relievers. They require diagnosis, medical oversight, infection screening, medication review, lab monitoring, and coordination with clinicians managing the autoimmune or inflammatory condition. Patients with lupus, Sjogren’s, vasculitis, undifferentiated connective tissue disease, inflammatory arthritis, or other systemic conditions may require careful specialist involvement before infusion decisions are made.

How Infusion Types Differ

The risks and goals of infusion therapy vary by medication. Ketamine therapy may involve sedation, dissociation, mood effects, nausea, dizziness, and blood pressure or heart rate changes. Lidocaine-based infusions may involve cardiac or neurologic risks and require appropriate screening and monitoring. Biologics may increase infection risk, cause infusion reactions, or require ongoing lab and medication review.

Because of these differences, MPM does not combine all infusions under one set of benefits or risks. The team reviews the patient’s medical history, medications, prior treatment response, mental health history, immune status, infection risk, cardiovascular risk, neurologic risk, and functional goals before recommending an infusion pathway.

What Patients Can Expect

Before an infusion, patients may need lab work, medical clearance, infection screening, medication adjustments, or coordination with another treating clinician. During the infusion visit, medication is administered through an IV or infusion system while the care team monitors safety and response. Depending on the infusion type, vital signs, sedation level, mood effects, neurologic symptoms, allergic reactions, or post-infusion recovery may be monitored.

After treatment, MPM reviews symptom response, side effects, function, and whether the infusion supported the intended goal. If treatment helps, future infusions may be considered at medically appropriate intervals. If it does not help or creates safety concerns, the care plan may be adjusted.

Infusions Within Coordinated Pain Care

Infusion therapy may be one part of a broader care plan. Patients with CRPS may also need rehabilitation, pain psychology, medication management, and functional restoration. Patients with autoimmune-related pain may need rheumatology coordination and disease-directed care. Patients with spine-related pain may need imaging review, procedures, physical therapy, or surgical consultation. Patients with headache disorders may need headache-specific treatment planning.

MPM’s role is to keep infusion therapy connected to the diagnosis, not separate from it. Infusions should not delay necessary evaluation, emergency care, or specialist treatment.

Risks and Urgent Symptoms

Infusion risks may include infusion reactions, allergic reactions, infection risk, blood pressure or heart rate changes, sedation, dizziness, nausea, dissociation or mood effects with ketamine, cardiac or neurologic risks with lidocaine, immune suppression with biologics, medication interactions, and condition-specific adverse effects.

Patients should seek urgent medical care for trouble breathing, chest pain, severe allergic reaction, fainting, severe confusion, severe sedation, new neurological deficits, fever, signs of infection, severe headache, severe abdominal or pelvic pain, bowel or bladder dysfunction, rapidly worsening weakness, or rapidly worsening symptoms.

For selected patients, infusion therapy may be a meaningful option within pain and inflammatory care. MPM’s role is to determine whether the treatment is medically appropriate, which infusion type fits the diagnosis, and how to monitor and coordinate care safely.