Ketamine therapy may be considered for selected patients with refractory chronic pain, neuropathic pain, CRPS, centralized pain, pelvic pain, or complex pain patterns.
Learn how Dr. Aranguren explains ketamine infusion therapy, how it may help manage chronic pain by calming the nervous system, and who may benefit from this treatment.
Our team organizes conditions and treatments into related zones of expertise to make it easier to explore the care paths most relevant to your symptoms and goals.
Use the zone tags above to browse dedicated pages for each focus area, including services, providers, and what to expect during treatment.
If your nervous system feels stuck in constant “fight or flight,” and chronic pain, anxiety, trauma, or mood symptoms are all overlapping together, ketamine therapy may be one option worth exploring.
Ketamine therapy is used in carefully controlled medical settings to help regulate the way the brain and nervous system process pain, stress, mood, and sensitization. Originally used as an anesthetic medication, ketamine is now being used in much lower doses to help patients with conditions like chronic neuropathic pain, central sensitization, PTSD, depression, anxiety, CRPS, and chronic pain syndromes that haven’t responded well to traditional treatments.
One of the reasons ketamine can be helpful is that chronic pain and chronic stress can change the way the nervous system functions over time. The brain can become more reactive, more protective, and more amplified. Ketamine works on specific receptors involved in pain signaling and nervous system sensitization, helping interrupt some of those patterns and allowing the system to become less “stuck.”
Treatment is done in a monitored setting, and every plan is individualized depending on the patient’s symptoms, goals, and overall health picture. My approach is always to combine ketamine therapy with a broader plan that may include rehabilitation, nervous system regulation, therapy, movement, medications, and addressing the underlying drivers of symptoms.
The goal is not simply temporary symptom relief. It’s helping patients regain function, improve quality of life, and create more flexibility within a nervous system that may have been overwhelmed for a long time.
If you’ve been dealing with chronic pain, nervous system symptoms, trauma-related symptoms, or severe flare patterns and feel like nothing else has helped enough, ketamine therapy may be something worth discussing with your care team.
Ketamine therapy is a medically supervised treatment that may be considered for selected patients with severe, refractory, neuropathic, centralized, CRPS-related, pelvic, headache-overlap, or complex chronic pain. It is not a wellness infusion, a first-line treatment, or a universal solution for pain.
At Manhattan Pain Medicine, ketamine therapy in NYC begins with a diagnosis-first evaluation that considers the patient’s pain condition, prior treatments, medications, medical risks, psychiatric history, autonomic symptoms, trauma history, and treatment goals. The goal is to determine whether ketamine may have a role in the broader care plan, not to use it as a standalone answer.
MPM specialists evaluate whether ketamine therapy may be appropriate by first clarifying the patient’s diagnosis and pain mechanism. Ketamine may be considered for selected patients with refractory neuropathic pain, CRPS, centralized pain, fibromyalgia, post-viral pain, pelvic nerve pain, or complex pain patterns when standard treatments have not provided enough relief. Candidacy requires careful review of medical history, medication interactions, blood pressure, cardiac risk, seizure history, liver considerations, psychiatric stability, substance use concerns, autonomic symptoms, and psychological safety.
MPM also considers whether ketamine should be coordinated with pain psychology, biofeedback, rehabilitation, medication management, procedures, or specialist care.
Patients often search for ketamine therapy in Manhattan after months or years of persistent pain that has not improved enough with medication, injections, physical therapy, pain psychology, biofeedback, acupuncture, or specialty care. Some patients have CRPS, small fiber neuropathy, fibromyalgia, chronic pelvic pain, migraine overlap, post-COVID pain, EBV-related pain, Medical PTSD, or severe centralized pain symptoms.
MPM approaches ketamine therapy as an advanced pain-modulating treatment for selected patients. It is different from ketamine treatment for depression or anxiety, although psychological safety and trauma-informed preparation are important. Ketamine may affect pain signaling pathways involved in central sensitization and refractory pain, but response varies and relief may be temporary. It can also cause sedation, dissociation, mood changes, nausea, anxiety, blood pressure or heart rate changes, urinary symptoms, liver considerations, and medication interactions. For that reason, MPM considers ketamine only within a medically supervised, diagnosis-first care plan.
Ketamine therapy may intersect with several MPM Zones of Expertise, including Complex Chronic Pain, Psychology of Pain, Musculoskeletal issues, Pelvic Pain, and Headache. For complex chronic pain, ketamine may be considered when symptoms remain severe despite standard treatment. For Psychology of Pain, MPM considers trauma history, fear of symptoms, dissociation risk, anxiety, Medical PTSD, and psychological readiness. For pelvic pain, ketamine may be considered only when the broader pain pattern suggests neuropathic, centralized, CRPS-like, or refractory pain mechanisms.
For headache and migraine overlap, MPM first evaluates the headache diagnosis and considers whether headache-specific treatment may be more appropriate. Ketamine is not used as a blanket treatment across these zones. It is considered only when the diagnosis, safety profile, symptoms, and goals support a medically supervised trial.
Before ketamine therapy, MPM reviews the treatment plan, preparation instructions, medications, safety considerations, monitoring needs, and post-treatment expectations. Depending on the patient, additional review of blood pressure, cardiac history, liver considerations, psychiatric history, medication interactions, or transportation planning may be needed. During treatment, ketamine is administered in a medically supervised setting while the care team monitors the patient’s response.
Patients may experience sedation, dissociation, altered perception, nausea, dizziness, anxiety, mood changes, blood pressure or heart rate changes, or other symptoms. The experience varies from patient to patient. After treatment, patients may need observation before leaving and should follow post-treatment instructions carefully. Follow-up helps determine whether ketamine provided meaningful benefit and whether the care plan should continue, change, or stop.
These guys are the best. I've been going here for over 6 years and their familiarity with my Schwannomatosis (most ppl have never even heard of it - its rather rare) and their ability to diagnose my CRPS quickly and accurately and then treat it like I was merely getting a flu shot is just incredible...
Highly recommended for those who need Pain Management. Everyone at Manhattan Pain Medicine is extremely nice and helpful. I have had very good interactions with both Dr. Siefferman and Dr. Louis. All of the staff is very responsive. 5 stars.
The providers at Manhattan Pain Medicine are exceptional. I wish I had found them 30 years ago!
I genuinely can’t say enough good things about the team at Manhattan Pain Medicine. I have MCAS, EDS, and an inflammatory autoimmune disease, and I’ve basically been searching for answers since I was a kid. I had years of unexplained inflammation markers, chronic pain, and allergic reactions despite...
I have a complex medical history and have seen a lot of doctors over the years. Dr. Mikaberidze and Dr. Siefferman each took the time to really listen and understand everything I had been dealing with. I also appreciated how they work together and communicated about my care. I left with a plan that...
Sharing my gratitude for the pleasant experience last week during my visit, the medical team provided great care and also treated my session as a learning experience, I left my session with a wealth of knowledge. A big thank you to the kind, and professional staff who welcomed me to the office as a...
I cannot say enough good things about Manhattan Pain Medicine. From the moment I walked in, I felt truly cared for and taken seriously. Dr. Nino Mikaberidze, Director of Rheumatology, is exceptional — knowledgeable, compassionate, and incredibly thorough. She takes the time to listen, explains every...
Dr Siefferman is the most thorough, patient doctor I have even been to. Currently I travel from miami to nyc to see him because his bed side manner and desire to help is incomparable.
ZocDoc
This practice is wonderful. I have been a patient of Dr. Siefferman’s since 2019 and he’s extremely helpful and kind. He has brought in a Rheumatologist who is also great. They handle very complex pain issues and always try to find new ways to help me.
Dr. Siefferman is an incredible doctor! He is extremely diligent and knowledgeable. It feels like you are his only patient. He invests a lot of time and effort into your injuries and concerns. I did not find these wonderful qualities with other pain specialists before, who were always rushed and som...
ZocDoc
Dr. Siefferman is a doctor who combines the old world bedside manner of doctors from my childhood (60 years ago) with a sta te of the art embrace of modern technology. It is always a pleasure to have an appointment with him...always has options and solutions to my medical issues. He is truly the doc...
ZocDoc
Dr. Siefferman is a genius. He is very informed and listens attentively.
ZocDoc
Dr. Siefferman and his entire team continue to be efficient, dedicated, and driven by precision and a genuine desire to give fantastic care. Will always recommend.
ZocDoc
Doctor Siefferman is fantastic. Have been seeing him for 5 years. Couldn’t recommend more.
ZocDoc
Dr. Siefferman is the ONLY doctor who has ever been able to diagnose my pain and treat it. He is hands down the best
ZocDoc
Ketamine therapy is a medically supervised treatment that may be considered for selected patients with refractory chronic pain, neuropathic pain, CRPS, centralized pain, pelvic pain, post-viral pain, or complex pain patterns. It is not a wellness IV and is not appropriate for every patient. Ketamine has different uses in medicine, including anesthesia, pain treatment, and certain mental health settings. At MPM, ketamine therapy is evaluated specifically through a diagnosis-first pain medicine lens.
Ketamine may help selected chronic pain patients by affecting NMDA receptor-related pain signaling pathways involved in central sensitization and refractory pain. It may be considered when pain remains severe despite standard treatments, especially in certain neuropathic, CRPS-related, or centralized pain patterns. Ketamine does not cure chronic pain, and response varies. MPM evaluates whether the patient’s diagnosis, prior treatment history, safety profile, and goals support ketamine therapy before recommending treatment.
Ketamine has FDA-approved uses in anesthesia, but ketamine therapy for chronic pain is generally considered off-label. Off-label use may still be considered in selected clinical situations, but it requires careful evaluation, informed discussion, medical supervision, and realistic expectations. MPM does not present ketamine as a guaranteed or routine solution. The decision depends on diagnosis, symptom pattern, prior treatments, safety factors, medication interactions, psychological safety, and treatment goals.
Ketamine may be considered for selected patients with complex regional pain syndrome when pain remains severe despite standard treatments. Some evidence suggests ketamine may help certain CRPS patients, but response varies and durable relief is not guaranteed. Ketamine does not cure CRPS and should not replace rehabilitation, pain psychology, medication management, sympathetic blocks, functional restoration, or coordinated care. MPM evaluates whether ketamine for CRPS NYC care fits the patient’s diagnosis, risks, and broader treatment plan.
Ketamine may be considered for selected neuropathic pain patterns, especially when nerve pain is severe, refractory, or associated with central sensitization. This may include certain patients with burning pain, allodynia, small fiber neuropathy symptoms, post-viral nerve pain, or complex nerve-related pain patterns. It does not cure neuropathy or replace evaluation for underlying causes. MPM reviews the diagnosis, medication history, neurologic symptoms, safety profile, and specialist input when appropriate before considering ketamine for neuropathic pain NYC care.
Ketamine may be considered for selected patients with fibromyalgia or centralized pain, but it is not a first-line treatment and does not cure these conditions. Centralized pain often requires coordinated care that may include pain psychology, biofeedback, pacing, sleep support, movement-based care, medication management, and evaluation for overlapping medical contributors. MPM considers ketamine therapy only when symptoms are refractory, safety factors are acceptable, and the treatment goal is clearly connected to the broader care plan.
Ketamine may be considered for selected chronic pelvic pain patterns, especially when symptoms suggest neuropathic, centralized, CRPS-like, or refractory pain mechanisms. This may include some patients with pudendal neuralgia, pelvic nerve pain, pelvic dystonia, PGAD-related distress, endometriosis-related pain overlap, or pelvic floor dysfunction. Ketamine does not replace pelvic specialty care, pelvic floor therapy, gynecology, urology, pain psychology, or nerve-targeted evaluation when needed. MPM evaluates the full pelvic pain pattern before considering ketamine.
Ketamine may be considered in selected headache or migraine contexts, but it is not appropriate for every headache disorder. Chronic migraine, cluster headache, hemicrania, tension headache, and trigeminal autonomic cephalalgias require careful headache classification. MPM evaluates headache diagnosis, neurological symptoms, medication history, red flags, and prior treatment response before considering ketamine for migraine NYC care. Many patients may need headache-specific treatment, medication management, nerve blocks, or additional neurological evaluation instead.
Ketamine therapy focuses on ketamine as the primary treatment. Lidocaine and ketamine infusions may involve different protocols, different medication combinations, and different monitoring needs. Lidocaine is an anesthetic medication that may be considered in certain neuropathic pain contexts and requires cardiac and neurologic safety review. Ketamine affects NMDA receptor-related pain pathways and requires monitoring for sedation, dissociation, mood effects, nausea, and blood pressure or heart rate changes. MPM determines which approach, if any, fits the clinical picture.
Ketamine for pain and ketamine for depression may involve different clinical goals, protocols, monitoring priorities, and follow-up plans. In pain medicine, ketamine may be considered for selected refractory neuropathic, CRPS-related, centralized, or complex pain patterns. Mental health ketamine treatment focuses on psychiatric indications and requires appropriate psychiatric evaluation and follow-up. At MPM, ketamine therapy is evaluated within a chronic pain care plan, while psychological safety, trauma history, mood, and psychiatric stability are still reviewed carefully.
MPM considers the patient’s diagnosis, pain mechanism, severity, prior treatments, medication history, medical risks, psychological safety, autonomic symptoms, cardiac history, seizure history, liver considerations, substance use concerns, pregnancy or breastfeeding considerations, and care goals. The team also reviews whether ketamine should be coordinated with pain psychology, biofeedback, procedures, neurology, rheumatology, pelvic specialty care, psychiatry, or primary care. Candidacy is individualized and requires a medically supervised plan.
Monitoring depends on the patient’s risk profile and treatment plan. Ketamine therapy may require monitoring for sedation, dissociation, mood changes, anxiety, nausea, vomiting, blood pressure changes, heart rate changes, respiratory concerns, and recovery before discharge. Some patients may need medication review, cardiac screening, psychiatric safety review, lab work, transportation planning, or coordination with other clinicians before treatment. MPM determines monitoring needs before therapy begins.
The length of ketamine therapy depends on the protocol, dose, monitoring needs, and patient response. The full visit may include preparation, baseline assessment, medication administration, monitoring during treatment, and recovery time afterward. Patients may need transportation planning and should follow post-treatment instructions carefully. MPM reviews the expected timing, preparation, and recovery plan before treatment based on the specific protocol being considered.
Repeat timing depends on the diagnosis, treatment response, side effects, duration of benefit, and medical judgment. Ketamine should not be repeated automatically. MPM evaluates whether the patient had meaningful benefit, how long any benefit lasted, whether side effects occurred, and whether the broader care plan should change. Some patients may not benefit enough to continue. Others may need coordinated treatment that includes rehabilitation, medications, pain psychology, procedures, or specialist care.
Ketamine therapy may involve sedation, dissociation, hallucinations, nausea, vomiting, blood pressure or heart rate changes, mood changes, anxiety, urinary symptoms, liver considerations, medication interactions, abuse or misuse concerns, and psychological safety considerations. Serious side effects are uncommon but possible, especially in higher-risk patients. MPM uses caution in patients with significant cardiac disease, uncontrolled hypertension, seizure history, severe liver disease, active psychosis, severe psychiatric instability, substance use concerns, pregnancy or breastfeeding considerations, or unstable medical conditions.
Ketamine therapy may need to be avoided or delayed with significant cardiac disease, uncontrolled hypertension, seizure history, severe liver disease, active psychosis, severe uncontrolled psychiatric instability, substance use concerns, pregnancy or breastfeeding considerations, medication interactions, unstable medical conditions, or unclear diagnosis. Urgent evaluation is needed for chest pain, trouble breathing, fainting, severe confusion, severe agitation, suicidal thoughts, new neurological deficits, seizure, severe allergic reaction, fever, severe abdominal or pelvic pain, bowel or bladder dysfunction, rapidly worsening weakness, or rapidly worsening symptoms.
Before care begins, our team helps patients understand the practical side of treatment, including insurance verification, out-of-network benefits, cost-share estimates, self-pay options, and billing questions. We believe patients should have as much clarity as possible before moving forward.
Ketamine therapy is a medically supervised treatment that may be considered for selected patients with refractory chronic pain, neuropathic pain, complex regional pain syndrome, centralized pain, fibromyalgia, chronic pelvic pain, post-viral pain, headache overlap, or complex pain patterns. It is not a wellness infusion, and it is not a first-line treatment.
At Manhattan Pain Medicine (MPM), ketamine therapy NYC care begins with diagnosis-first evaluation. The goal is to understand the patient’s pain mechanism, prior treatment response, medical risks, psychological context, autonomic symptoms, and treatment goals before deciding whether ketamine belongs in the care plan.
Ketamine affects NMDA receptor-related pain signaling pathways that may be involved in central sensitization and some refractory pain states. This may be relevant for selected patients whose pain remains severe despite standard medications, injections, physical therapy, procedures, pain psychology, biofeedback, acupuncture, or specialty care.
Ketamine for chronic pain NYC care may be considered in selected cases of CRPS, neuropathic pain, small fiber neuropathy symptoms, fibromyalgia, centralized pain, pelvic nerve pain, post-COVID pain, EBV-related pain, or severe complex chronic pain. Response varies, and relief may be temporary. Ketamine does not cure the underlying condition, and it should not replace coordinated medical care.
Ketamine infusions for complex regional pain syndrome NYC care may be considered when CRPS symptoms are severe, refractory, and functionally limiting. Some patients with CRPS experience allodynia, burning pain, color or temperature changes, swelling, movement sensitivity, or severe pain amplification. Ketamine may help selected patients reduce pain burden, but it should be part of a broader plan that may include rehabilitation, pain psychology, sympathetic blocks, medication management, and functional restoration.
Ketamine treatment for refractory neuropathic pain may also be considered in selected patients with burning pain, nerve sensitivity, small fiber neuropathy symptoms, or post-viral neuropathic symptoms. MPM evaluates whether additional neurologic workup, medication review, autonomic evaluation, or specialist care is needed before treatment.
Some patients with chronic pelvic pain, pudendal neuralgia, pelvic dystonia, PGAD-related distress, pelvic floor dysfunction, or endometriosis-related pain overlap may ask whether ketamine can help. MPM considers ketamine only when the broader pain pattern suggests refractory neuropathic, centralized, or CRPS-like features. Pelvic specialty care, pelvic floor therapy, gynecology, urology, pain psychology, and nerve-targeted treatment may still be needed.
Patients with chronic migraine or headache overlap require careful headache classification before ketamine is considered. Many headache disorders have more specific treatment pathways, including medication management, nerve blocks, botulinum toxin for chronic migraine, trigger point injections, or neurological evaluation.
Ketamine can affect perception, mood, and the sense of body awareness. For some patients, this is manageable with preparation and monitoring. For others, especially patients with Medical PTSD, dissociation, anxiety, severe trauma responses, autonomic instability, or prior distressing medical experiences, ketamine requires careful planning.
MPM considers psychological safety as part of ketamine candidacy. This does not mean pain is psychological. It means the experience of ketamine can interact with trauma history, mood, anxiety, body alarms, and nervous system sensitivity. Pain psychology or additional mental health support may be appropriate before, during, or after treatment.
Ketamine therapy may involve sedation, dissociation, hallucinations, nausea, vomiting, blood pressure or heart rate changes, mood changes, anxiety, urinary symptoms, liver considerations, medication interactions, abuse or misuse concerns, and psychological safety considerations. MPM uses caution in patients with significant cardiac disease, uncontrolled hypertension, seizure history, severe liver disease, active psychosis, severe uncontrolled psychiatric instability, substance use concerns, pregnancy or breastfeeding considerations, medication interactions, or unstable medical conditions.
Patients may need medication review, blood pressure review, cardiac screening, lab work, psychiatric safety review, transportation planning, or coordination with other clinicians before treatment.
Ketamine therapy works best when it is connected to the rest of the pain plan. A patient may also need medication management, rehabilitation, pain psychology, biofeedback, acupuncture, procedures, neurology, rheumatology, pelvic specialty care, or headache-specific treatment. MPM monitors whether ketamine changes pain intensity, function, flare patterns, mood, autonomic symptoms, or treatment tolerance.
Patients should seek urgent evaluation for chest pain, trouble breathing, fainting, severe confusion, severe agitation, suicidal thoughts, new neurological deficits, seizure, severe allergic reaction, fever, severe abdominal or pelvic pain, bowel or bladder dysfunction, rapidly worsening weakness, or rapidly worsening symptoms.
For selected patients, ketamine therapy may be a meaningful advanced tool in complex pain care. MPM’s role is to determine whether the diagnosis, safety profile, monitoring needs, and treatment goals support its use within a coordinated, medically supervised plan.
